Here's the disclaimer: I *think* this photo is of the old Ghiradelli building! I don't quite remember if we verified the address before taking the picture. If it's not it, then it's a neighbor. :-)
It was into this building and neighboring ones (more or less :-) ) that Domenico Ghiradelli housed the original Ghiradelli Chocolate Manufactory in 1857. It wasn't until 1893 that the company moved to its more well-known location on Beach Street: Ghiradelli Square (which is NOT pictured here!).